I really don't see this as a sure-win for Denver. KC has a pretty stout Def and will probably shut down Denver's running game, which will give KC a lot of chances for pics, not to mention Manning may be a little hurt. A couple of sacks and this game might get away from Denver. Still, the problem is that Denver has so many air targets KC will have to cover man-to-man and Peyton is a master of shredding man-to-man. Den Def better step up or JC is going to do a little shredding of his own.
I don't see this as a runaway for Denver, but I think they'll win something like 28-21.