I actually think the SD/NE will not be a repeat of the MIA/NE game. It will be a lower scoring game. Week one is always tough to evaluate Defenses unless you are the Baltimore Ravens lol. But I's stick w/ SD. But the HOU def. is a solid match-up against MIA. Just depends on if you are willing to risk losing the SD def. to someone else.
Keep Tolbert, Moreno got banged up again in the loss against OAK. Denver is going to be playing catch up a lot this year so unless you're in a PPR league let some one deal with the ups and DOWNS which Moreno brings week in and week out.