I am dealing with similar problem. I have Hilton and Crabtree - both bad matchups. We start 3 wrs and Snead, Shepard, and Hurns round out my stable. Due to starting 3 their is no way I can leave Hilton on the bench. Shepard has a juicy matchup, so he will be my 2 this week. I am seriously thinking about swapping Snead or Hurns in for Crabtree who is nicked up and plays Denver, a team last year that shut him down. I would love to know your opinion on my situation...
As to your situation - Hilton could very easily give you a 4 point game and Hurns could go 5-80-1, however with your prowess with Jones and Hopkins you will get points from your WR. I think Hurns has a very low ceiling and I can't see Jags replicating their offensive explosion from last week even though they have the Jets. Look what Hurns did last week in a high scoring game. Good, not great. Hilton is a far better talent and odds say he will not have a great game, but he is also a player that can go 3-120-2. I would roll with Hilton. If he puts up a stinker you may lose 10 points compared to Hurns, but the reward is that he could outscore Hurns by 20 if he can break free on a play or two.