in PPR leagues, yes, Andre Johnson is the clear favorite.
Otherwise it's pretty close. Both have been very consistent the past few years. They both have obvious negatives when you look closely at their stats:
Andre Johnson: Last year he had his personal best year...with 9 TDs. Only 9? And now Houston is showing signs of using Foster as a featured running back who won't fumble like Slaton did. Andre Johnson will be good, but I put his ceiling at 10.
Randy Moss caught 46% of New England's TDs last year. Very high percentage. Fluky? I expect Brady to pass for slightly more TDs than his 28 last year, but if things normalize Randy Moss should get less than his 13 last year.
With that said, Randy Moss has a higher ceiling. But can be looked at a higher risk with his age and history of injuries.
So do you want the safer pick or the risky pick and get a guy who could get 12+ TDs? Up to you.