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Something I've done in the past is get as many players on one bye week as possible. i basically give up that week to ensure the rest of the season is smooth.
Otherwise, you just need good replcements.
1st pick in a 12 team 2QB PPR IDP (what a league).
1) David Johnson
2) Dez Bryant
3) Doug Baldwin
4) Phillip Rivers
5) Andy Dalton
6) Mark Ingram
7) Luke Kuechly
8) Tyler Eifert
9) Willie Snead
10) Deshaun Watson
11) Donte Moncreif
12) Jacquizz Rodgers
13) Corey Davis
14) Cameron Brate
15) Deandre Washington
16) Josh McCown
17) Carolina DEF
18) Cairo Santos
19) Jason Pierre Paul
I think I did decently for my starters but my depth needs work.
It all depends how many RB and WR you start every week! If you have to sit one of those 3 rbs than ya trade him for a better WR (someone like jordy, evans)