cliaz Posted June 29, 2007 Share Posted June 29, 2007 http://news.yahoo.com/s/afp/20070628/hl_af...Zkjs3UPh6Ba24cA Potential cure for HIV discovered by Mira Oberman Thu Jun 28, 2:39 PM ET CHICAGO (AFP) - In a breakthrough that could potentially lead to a cure for HIV infection, scientists have discovered a way to remove the virus from infected cells, a study released Thursday said. The scientists engineered an enzyme which attacks the DNA of the HIV virus and cuts it out of the infected cell, according to the study published in Science magazine. The enzyme is still far from being ready to use as a treatment, the authors warned, but it offers a glimmer of hope for the more than 40 million people infected worldwide. "A customized enzyme that effectively excises integrated HIV-1 from infected cells in vitro might one day help to eradicate (the) virus from AIDS patients," Alan Engelman, of Harvard University's Dana-Farber Cancer Institute, wrote in an article accompanying the study. Current treatments focus on suppressing the HIV virus in order to delay the onset of AIDS and dramatically extend the life of infected patients. What makes HIV so deadly, however, is its ability to insert itself into the body's cells and force those cells to produce new infection. "Consequently the virus becomes inextricably linked to the host, making it virtually impossible to 'cure' AIDS patients of their HIV-1 infection," Engelman explained. That could change if the enzyme developed by a group of German scientists can be made safe to use on people. That enzyme was able to eliminate the HIV virus from infected human cells in about three months in the laboratory. The researchers engineered an enzyme called Tre which removes the virus from the genome of infected cells by recognizing and then recombining the structure of the virus's DNA. This ability to recognize HIV's DNA might one day help overcome one of the biggest obstacles to finding a cure: the ability of the HIV virus to avoid detection by reverting to a resting state within infected cells which then cease to produce the virus for months or even years. "Numerous attempts have been made to activate these cells, with the hope that such strategies would sensitize the accompanying viruses to antiviral drugs, leading to virus eradication," Engelman wrote. "Advances with such approaches in patients have been slow to materialize." New experiments must be designed to see if the Tre enzyme can be used to recognize these dormant infected cells, he wrote. "Although favorable results would represent perhaps only a baby step toward eventual use in patients, the discovery of the Tre recombinase proves that enzymatic removal of integrated HIV-1 from human chromosomes is a current-day reality," he said. The researchers who developed the enzyme were optimistic about their ability to design additional enzymes which would target other parts of the virus's DNA. However they warned that there were significant barriers to overcome before the enzyme could be used to help cure patients. "The most important, and likely most difficult, among these is that the enzyme would need efficient and safe means of delivery and would have to be able to function without adverse side effects," wrote lead author Indrani Sarkar of the Max Planck Institute for Molecular Cell Biology and Genetics in Dresden. "Nevertheless the results we present offer an early proof of principal for this type of approach, which we speculate might form a useful basis for the development of future HIV therapies," Sarkar concluded. Quote Link to comment Share on other sites More sharing options...
muck Posted June 29, 2007 Share Posted June 29, 2007 Science is, frankly, pretty darn cool. An enzyme that "recognizes" DNA? Where's Dr. McCoy now?! Thanks for the article. Quote Link to comment Share on other sites More sharing options...
polksalet Posted June 29, 2007 Share Posted June 29, 2007 It's all funny until the cured people suck you life out through their palms. Quote Link to comment Share on other sites More sharing options...
Chavez Posted June 29, 2007 Share Posted June 29, 2007 Fantastic! We have moved forward from the inhuman "don't smoke dick" prevention method to a cure. Quote Link to comment Share on other sites More sharing options...
Bill Swerski Posted June 29, 2007 Share Posted June 29, 2007 An enzyme that "recognizes" DNA? There are all sorts of naturally-occurring enzymes that recognize DNA... not to mention enzymes that recognize RNA, proteins, and saccharides as well. You probably have trace amounts of them on your hands right now. "The most important, and likely most difficult, among these is that the enzyme would need efficient and safe means of delivery and would have to be able to function without adverse side effects ," wrote lead author Indrani Sarkar of the Max Planck Institute for Molecular Cell Biology and Genetics in Dresden. Hate to rain on the parade, but that might be an issue. It's definitely an important discovery, but I'm going to save my enthusiasm until it makes it through Phase I clinical trials. Quote Link to comment Share on other sites More sharing options...
Azazello1313 Posted June 29, 2007 Share Posted June 29, 2007 Hate to rain on the parade, but that might be an issue. It's definitely an important discovery, but I'm going to save my enthusiasm until it makes it through Phase I clinical trials. yeah, chavez, don't run out to smoke a bunch of dick just yet. Quote Link to comment Share on other sites More sharing options...
Bill Swerski Posted June 29, 2007 Share Posted June 29, 2007 yeah, chavez, don't run out to smoke a bunch of dick just yet. Quote Link to comment Share on other sites More sharing options...
Chavez Posted June 29, 2007 Share Posted June 29, 2007 yeah, chavez, don't run out to smoke a bunch of dick just yet. Quote Link to comment Share on other sites More sharing options...
dmarc117 Posted June 29, 2007 Share Posted June 29, 2007 yeah, chavez, don't run out to smoke a bunch of dick just yet. now that wouldve made the chicago get-together interesting Quote Link to comment Share on other sites More sharing options...
Azazello1313 Posted June 29, 2007 Share Posted June 29, 2007 now that wouldve made the chicago get-together interesting hey, if that's what it takes to get you and brent to show up... Quote Link to comment Share on other sites More sharing options...
Chargerz Posted June 30, 2007 Share Posted June 30, 2007 This whole area of enzyme therapy shows great promise. It could be used to cure many types of infections and cancers by removing the abnormal DNA from the affected cells. I really think it will happen, but not soon enough for me! Quote Link to comment Share on other sites More sharing options...
jetsfan Posted June 30, 2007 Share Posted June 30, 2007 Fantastic! We have moved forward from the inhuman "don't smoke dick" prevention method to a cure. SO that's how all those women and children get AIDs....go figure? Quote Link to comment Share on other sites More sharing options...
Avernus Posted June 30, 2007 Share Posted June 30, 2007 Quote Link to comment Share on other sites More sharing options...
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